Mechanistic representation of TTFields action on tumor cells

Explore the multiple, distinct anticancer mechanisms of TTFields

The multiple, distinct mechanisms of TTFields therapy work together to selectively target and kill cancer cells^1-5

Select a mechanism to learn more about its function

Depiction of TTFields interfering with cancer cell mitosis

Disruption of Mitosis

Cell exposed to TTFields with lateral electric field arrows

Interference with cell movement and migration

TTFields icon with concentric targeting indicators

Enhancement of antitumor immunity

Simplified diagram showing TTFields-induced molecular changes

Downregulation of DNA damage response

Desktop version of TTFields action across multiple mechanisms

TTFields therapy is clinically versatile, rooted in its multifaceted effects on cancer cells^1-3

See how TTFields harness physics to disrupt mitosis

References: 1. Karanam NK, Story MD. An overview of potential novel mechanisms of action underlying tumor treating fields-induced cancer cell death and their clinical implications. Int J Radiat Biol. 2021;97(8):1044-1054. doi:10.1080/09553002.2020.1837984 2. Voloshin T, Schneiderman RS, Volodin A, et al. Tumor treating fields (TTFields) hinder cancer cell motility through regulation of microtubule and actin dynamics. Cancers (Basel). 2020;12(10):1-18. doi:10.3390/cancers12103016 3. Hall A. The cytoskeleton and cancer. Cancer Metastasis Rev. 2009;28(1-2):5-14. doi:10.1007/s10555-008-9166-3 4. Giladi M, Schneiderman RS, Voloshin T, et al. Mitotic spindle disruption by alternating electric fields leads to improper chromosome segregation and mitotic catastrophe in cancer cells. Sci Rep. 2015;5:1-16. doi:10.1038/srep18046 5. Kirson ED, Dbalý V, Tovaryš F, et al. Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proc Natl Acad Sci U S A. 2007;104(24):10152-10157. doi:10.1073/pnas.0702916104