Home Multiple Mechanisms DNA Damage Response Disruption

TTFields downregulate genes important for DNA damage repair1,2

Double-strand break as a result of TTFields-induced disruption of DNA damage repair

TTFields downregulate genes important for DNA replication and DNA damage response pathways in cancer cells.1,2

Watch below to see how TTFields disrupt DNA damage repair

Evidence has proven TTFields' ability to disrupt DNA damage repair by downregulating genes that are part of the well known FA-BRCA pathway.1,2

See the enhanced effects of TTFields when used with an agent that inhibits DNA damage repair

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Double-strand break as a result of TTFields-induced disruption of DNA damage repair

References: 1. Karanam NK, Srinivasan K, Ding L, Sishc B, Saha D, Story MD. Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines. Cell Death Dis. 2017;8(3):1-10. doi:10.1038/cddis.2017.136 2. Karanam NK, Ding L, Aroumougame A, Story MD. Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: implications for cancer therapy. Transl Res. 2020;217:33-46. doi:10.1016/j.trsl.2019.10.003